Chemotherapy and side effects


Nausea: A feeling of sickness or discomfort in the stomach that may come with an urge to vomit.  

Nausea and vomit

  • Nausea is when you feel sick to your stomach, like you are going to throw up. Vomiting is when you throw up.
  • There are three patterns of nausea and vomiting associated with chemotherapy: acute, delayed, and anticipatory
  • It is a common problem
  • 70 to 80% have had nausea and vomiting
  • It is preventable
  • Quality of Life  cost

Nausea and vomit Etiology

  • Drugs
  • Intestinal obstruction
  • Gastric carcinoma
  • Infections
  • Vertigo
  • Metabolic disorders
  • Psychological factors
  • Radiotherapy
  • Toxins
  • Increased ICP
Semin Oncol  2000 27: 24-33

Nausea and vomit, Mucositis NCI-CTCAE Grading Scale

Grados

Manifestaciones

Grade 0

Normal

Grade 1

Transitional

Grade 2

Controllable

Grade 3

Requires therapy

Grade 4

Incontrolable

 



Regimen antiemético para emesis tardía

Riesgo

Regimen antiemético

Dosis y esquemas

Riesgo severo

Esteroides VO+metoclopra, Mida VO + 5HT3 VO

Dexametasona 8mg C/24 horas 3 a 4d

Riesgo moderado

Esteroides VO+metoclopra, Mida VO + 5HT3 VO

Metoclopramida 30mg O 0.5 mg/kg 2 a 4 v/d por 2 a 4 días

Riesgo bajo y muy bajo

No se dan antieméticos preventivos



Semin Oncol 1998; 25, 577-583

Complications of mouth

  • Dental
    • Caries
  • Soft tissue
    • Mucositis
    • Pericorinitis
    • Gingivitis
    • Periodontitis
    • Angular cheilosis
    • Xerostomia

Risk factors for complications of mouth

  • Weakness
  • Dry Mouth
  • Chemotherapy
  • Poor intake
  • Local radiation
  • Dehydration
   
British Medical Journal 315 (7114) 1002-1005





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